$pathological fracture cancer$ $pathological fracture cancer$

With its rapid relief for patients, PKP appears to be required for patients with painful pathological spinal fracture. Compared with PVP, PKP is more effective in restoring kyphosis due to the propulsive effect of the balloon ( 6). Percutaneous vertebral augmentation includes percutaneous vertebroplasty (PVP) and percutaneous kyphoplasty (PKP). With the development of minimally invasive surgery, percutaneous vertebral augmentation has been considered a preferred alternative for painful spinal metastases. Due to cachexia status and lower life expectancy of end-stage patients, extensive open surgery may not be tolerated and would significantly increase mortality ( 5). The compression on the abdominal organs and lungs caused by excessive kyphosis decreases appetite and affects pulmonary function ( 4). Besides, many patients are left with kyphosis despite the relieved pain. Conservative analgesic treatment, radiotherapy, chemotherapy, and other means hardly achieve satisfactory clinical results for pathologic spine fracture patients ( 3). Pathological fractures, characterized by severe pain and loss of motility, have brought great suffering to patients with end-stage lung cancer.ĭifferent from the obvious limitation of movement after pathological fractures of extremities, pathologic spine fractures are usually featured with prolonged back pain. Although 50% of bone metastases of lung cancer are asymptomatic, they often lead to serious complications ( 2). Bone is the most frequent site of distant metastases of lung cancer, especially the spine, femur, ribs, and sternum ( 1). Among the numerous types of cancer, lung cancer has gained widespread attention because of its high incidence and mortality rate. However, PKP could not improve the survival rate of patients.Ĭonclusion: PKP can be used as an effective palliative care treatment for patients with metastatic pathologic spinal fractures of lung cancer.Ĭancer has been a major challenge to global health. QALY indicated a better life quality brought by PKP. The ratio of moderate dependence after fracture was clearly increased by PKP. Results: PKP significantly corrected the kyphosis compared with conservative treatment. Patients' survival was carefully recorded. The life dependence and quality of the patients were evaluated by the Barthel Index of activities of daily living (ADL) and the quality-adjusted life year (QALY). The correction of kyphosis was assessed by the Cobb angle. Methods: A cohort study was conducted on 54 cases with pathologic spine fractures caused by metastasis of lung cancer. The clinical efficacy and safety of PKP for metastatic spinal lesions are urgently to be evaluated. Percutaneous kyphoplasty (PKP) has been considered a preferred alternative for painful spinal metastases. Department of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Chinaīackground: Pathological spine fractures caused by metastases of lung cancer have brought great suffering to patients.Jun-xin Zhang †, Zhuo-run Song †, Jun Zou, Jun Ge* and Hui-lin Yang*

$pathological fracture cancer$

Pathological fracture cancer